Castañon-Gonzalez J A, Eid-Lidt G, Wacher N, Gallegos-Perez H, Miranda-Ruiz R
Critical Care Medicine Unit, Hospital de Especialidades, Dr. Bernardo Sepúlveda G., Instituto Mexicano del Seguro Social, Mexico.
Acta Anaesthesiol Scand Suppl. 1995;107:219-22. doi: 10.1111/j.1399-6576.1995.tb04362.x.
To demonstrate that pentoxifylline (PTX) and not placebo improves oxygen consumption (VO2) in critically ill patients with severe sepsis.
Multidisciplinary intensive care unit in a university affiliated hospital.
A randomized, double blinded clinical trial comparing 300 mg of PTX administered in a 120 min iv infusion with an identically looking placebo.
13 patients (9 men and 4 women) average age 39 (24-62) years old received PTX, and 12 patients (5 men and 7 women) average age 38 (21-83) years old received placebo. All satisfied ACCP/SCCM criteria for severe sepsis.
Patients fulfilling criteria for severe sepsis was identified on admission, cardiac output, DO2 and VO2 were measured by thermodilution and standard oximetric technics after adequate volume replacement at baseline, 60 and 120 during infusion. F-test of analysis of variance was used to test hypothesis about differences of DO2 and VO2 by group, by time and for the interaction terms, a "p" value < 0.05 was considered significant.
Evaluation of baseline measurements of both groups revealed no significant difference in any haemodynamic function or oxygen transport variables. The average VO2 difference (0-120 min) between groups was 21 mL/min.m2 and it was higher in the experimental group, however, this difference was non significant.
We think that the trend in VO2 followed by the experimental group is clinically important. If this difference is sustained we will probably be able to demonstrate our hypothesis.
证明己酮可可碱（PTX）而非安慰剂可改善重症脓毒症患者的氧耗量（VO2）。
大学附属医院的多学科重症监护病房。
一项随机、双盲临床试验，比较静脉输注120分钟的300毫克PTX与外观相同的安慰剂。
13例患者（9例男性，4例女性），平均年龄39（24 - 62）岁，接受PTX治疗；12例患者（5例男性，7例女性），平均年龄38（21 - 83）岁，接受安慰剂治疗。所有患者均符合ACCP/SCCM重症脓毒症标准。
入院时确定符合重症脓毒症标准的患者，在基线、输注60分钟和120分钟时，经充分补液后，通过热稀释法和标准血氧测定技术测量心输出量、氧输送（DO2）和氧耗量（VO2）。采用方差分析的F检验来检验关于DO2和VO2在组间、时间以及交互项差异的假设，“p”值<0.05被认为具有统计学意义。
两组基线测量值评估显示，任何血流动力学功能或氧输送变量均无显著差异。两组间平均VO2差值（0 - 120分钟）为21毫升/分钟·平方米，实验组更高，但该差异无统计学意义。
我们认为实验组VO2的变化趋势具有临床重要性。如果这种差异持续存在，我们可能能够证明我们的假设。
