van den Oord J J, De Wolf-Peeters C
Department of Pathology II, University Hospital St. Rafael, Katholieke Universiteit Leuven, Belgium.
Am J Dermatopathol. 1995 Jun;17(3):266-70. doi: 10.1097/00000372-199506000-00009.
Perivascular spaces were found to represent a useful histological clue to the diagnosis of eccrine spiradenoma. They were observed in eight of nine eccrine spiradenomas but not in syringomas, nodular basal cell carcinomas, or glomangiomas. Perivascular spaces in spiradenomas consisted of variably sized spaces around one or more central blood vessels, bordered at the periphery by a palisade of tumor cells and lined at both sides by basement membrane collagen type IV. Perivascular spaces contained variable numbers of T lymphocytes in all cases and could undergo fibrosis, cystic dilatation, or hyalinization. In analogy to similar structures in thymomas, we suggest that perivascular spaces in spiradenomas are involved in the traffic of lymphocytes toward the tumor.
血管周围间隙被发现是诊断小汗腺螺旋腺瘤的一个有用的组织学线索。在9例小汗腺螺旋腺瘤中有8例观察到了血管周围间隙，而在汗管瘤、结节性基底细胞癌或血管球瘤中未观察到。螺旋腺瘤中的血管周围间隙由围绕一根或多根中央血管的大小不一的间隙组成，外周由一层肿瘤细胞栅栏状排列包绕，两侧由IV型基底膜胶原衬里。在所有病例中，血管周围间隙含有数量不等的T淋巴细胞，并且可发生纤维化、囊性扩张或玻璃样变。类似于胸腺瘤中的类似结构，我们认为螺旋腺瘤中的血管周围间隙参与淋巴细胞向肿瘤的移动。
