Dommann S N, Dommann-Scherrer C C, Zimmerman D, Dours-Zimmermann M T, Hassam S, Burg G
Department of Dermatology, University Hospital Zurich, Switzerland.
Am J Dermatopathol. 1995 Dec;17(6):618-24. doi: 10.1097/00000372-199512000-00017.
Cutaneous B-cell lymphomas constitute approximately 20% of primary cutaneous lymphomas. Most histologic subtypes of nodal B-cell lymphomas also occur primarily in the skin. The recently described T-cell-rich B-cell lymphomas (TCRBCLs) manifest mainly in the lymph nodes. This article presents a case of TCRBCL arising primarily in the skin, the origin of which could be traced back 13 years. The patient is a 59-year-old man. Plaque-like and nodular skin infiltrates had first appeared in the left preauricular region. Repeated examinations never found any extracutaneous involvement. A skin biopsy and a retrospectively studied 10-year-old skin specimen showed identical histologic features. Immunohistochemistry identified the TCRBCL previously considered as cutaneous Hodgkin's disease or a diffuse centroblastic centrocytic non-Hodgkin's lymphoma. A clonal B-cell population was detected by polymerase chain reaction, showing a rearrangement of IgH gene. The case of this patient shows that primary cutaneous TCRBCLs, similarly to other B-cell lymphomas in the skin, may have a good prognosis, in contrast to their nodal counterparts.
皮肤B细胞淋巴瘤约占原发性皮肤淋巴瘤的20%。大多数淋巴结B细胞淋巴瘤的组织学亚型也主要发生于皮肤。最近描述的富于T细胞的B细胞淋巴瘤（TCRBCL）主要表现在淋巴结。本文报告1例主要发生于皮肤的TCRBCL，其发病可追溯到13年前。患者为一名59岁男性。斑片状和结节状皮肤浸润最初出现在左耳前区。反复检查从未发现任何皮肤外受累情况。皮肤活检以及对一份回顾性研究的10年前的皮肤标本检查显示出相同的组织学特征。免疫组化确定该TCRBCL之前被认为是皮肤霍奇金病或弥漫性中心母细胞性中心细胞性非霍奇金淋巴瘤。通过聚合酶链反应检测到克隆性B细胞群，显示IgH基因重排。该患者病例表明，原发性皮肤TCRBCL与皮肤中的其他B细胞淋巴瘤一样，可能预后良好，这与它们在淋巴结中的对应情况不同。
