Kost'álová L, Misíková Z, Furková K, Lebl J, Simková E, Krásnicanová H
II. Detská klinika DFNsP, Bratislava.
Cas Lek Cesk. 1995 Dec 13;134(24):788-90.
Growth retardation is a serious problem in children with chronic renal failure (CRF) despite normal endogenous growth hormone (GH) secretion. Intensive medical care and dialysis do not improve height velocity. The aim of the study was to evaluate the efficacy of GH therapy in children with growth retardation secondary to CRF.
Biosynthetic growth hormone was given to 7 prepubertal children (five boys and 2 girls, age with a range 3.5-14.5 years) with severe growth retardation and CRF during 1 year. The dosage of GH was 1 IU/kg/per week. GH was given daily, sc. The patients had a full examination every 3 months. Six children completed the study. Height velocity improved with GH therapy in 5 children. Renal function deterioration was accelerated in 2 children. The serum alkaline phosphatase concentration increased and the serum calcium concentration decreased during GH treatment in all children. Glucose, thyroid gland hormone concentration and lipid concentrations remained constant.
The study showed clearly that treatment with biosynthetic GH gave an impressive improvement of height velocity in growth retarded prepubertal children with CRF.
尽管内源性生长激素（GH）分泌正常，但生长迟缓仍是慢性肾衰竭（CRF）患儿面临的一个严重问题。强化医疗护理和透析并不能提高身高增长速度。本研究的目的是评估生长激素治疗继发于慢性肾衰竭的生长迟缓患儿的疗效。
对7名患有严重生长迟缓和慢性肾衰竭的青春期前儿童（5名男孩和2名女孩，年龄在3.5至14.5岁之间）进行了为期1年的生物合成生长激素治疗。生长激素的剂量为每周1 IU/kg。生长激素每日皮下注射。患者每3个月进行一次全面检查。6名儿童完成了研究。5名儿童的身高增长速度在生长激素治疗后有所改善。2名儿童的肾功能恶化加速。所有儿童在生长激素治疗期间血清碱性磷酸酶浓度升高，血清钙浓度降低。血糖、甲状腺激素浓度和血脂浓度保持不变。
该研究清楚地表明，生物合成生长激素治疗使患有慢性肾衰竭的青春期前生长迟缓儿童的身高增长速度得到了显著改善。
