Allen S M, Duffy J P, Darnton S J, Cullen M H, Matthews H R
Regional Department of Thoracic Surgery and Oesophageal Research Laboratory, Birmingham Heartlands Hospital, UK.
Cancer Chemother Pharmacol. 1996;37(5):496-8. doi: 10.1007/s002800050418.
We evaluated the effect of brief neoadjuvant chemotherapy in patients with apparently operable adenocarcinoma of the oesophagus. Two courses of mitomycin (6 mg/m2), ifosfamide (3 g/m2) and cisplatin (50 mg/m2;MIC) were given followed by evaluation of response by barium swallow and computed tomography scan. Of 20 patients, 17 completed both courses and 4 (20%) showed a partial response. Toxicity was generally mild and consisted principally of nausea and vomiting. Altogether, 15 patients were surgically explored; resection was completed in 12 patients, 3 of whom died in hospital (25%). Neoadjuvant therapy with MIC offers no advantage over surgery alone.
