Berry F, Brown I R
Department of Zoology, University of Toronto, Ontario, Canada.
J Neurosci Res. 1995 Dec;42(5):613-22. doi: 10.1002/jnr.490420503.
The expression of calmodulin (CaM) protein and mRNA was analyzed in specific regions of the rat brain during postnatal development. CaM levels in the adult brain were more abundant in the cerebral hemispheres and thalamus compared to brain stem and superior plus inferior colliculus. All brain regions contained higher CaM protein and mRNA levels than in non-neural tissues such as the kidney. During postnatal development of the brain, maximal levels of CaM protein and CaM I mRNAs were attained at day 10 or 15. Protein levels declined thereafter in the adult in all regions except the thalamus. With respect to products of the rat CaM I gene, the 4.0 kb neural transcript demonstrated a pronounced increase during postnatal development, whereas the 1.8 kb message showed little change.
在出生后发育过程中，对大鼠脑特定区域的钙调蛋白（CaM）蛋白和mRNA表达进行了分析。与脑干以及上、下丘相比，成年大脑中CaM水平在大脑半球和丘脑中更为丰富。所有脑区的CaM蛋白和mRNA水平均高于非神经组织，如肾脏。在脑的出生后发育过程中，CaM蛋白和CaM I mRNA的最高水平在第10天或第15天达到。此后，除丘脑外，所有区域的蛋白水平在成年期均下降。关于大鼠CaM I基因的产物，4.0 kb的神经转录本在出生后发育过程中显著增加，而1.8 kb的转录本变化不大。
