Fernández V, Videla L A
Departamento de Bioquimica, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Toxicol Lett. 1996 Mar;84(3):149-53. doi: 10.1016/0378-4274(95)03617-2.
The influence of daily doses of 0.1 mg 3,3',5-triiodothyronine (T3)/kg for three consecutive days on hepatic lipid peroxidation was assessed by the biliary release of thiobarbituric acid reactants (TBARS) in anesthetized rats. T3 treatment elicited a significant 80% increase in the biliary efflux of TBARS compared to control values, an effect determined by increments in both the TBARS concentration in bile (44%) and in the bile flow (25%). It is concluded that hyperthyroidism-induced oxidative stress stimulates hepatic lipid peroxidation measured in an in situ liver preparation, which significantly correlates with the enhancement in the rate of TBARS production assessed in liver homogenates.
连续三天每天给予0.1毫克3,3',5-三碘甲状腺原氨酸（T3）/千克，通过测定麻醉大鼠胆汁中硫代巴比妥酸反应物（TBARS）的释放来评估其对肝脏脂质过氧化的影响。与对照组相比，T3处理使胆汁中TBARS的流出量显著增加了80%，这一效应是由胆汁中TBARS浓度增加（44%）和胆汁流量增加（25%）共同决定的。得出的结论是，甲状腺功能亢进诱导的氧化应激刺激了原位肝制剂中测定的肝脏脂质过氧化，这与肝脏匀浆中评估的TBARS产生速率的提高显著相关。
