Pella J, Stancák B, Komanová E, Novotný R
III. interná klinika FN L. Pasteura, Kosice.
Vnitr Lek. 1995 Dec;41(12):832-5.
In the submitted case-history the authors describe a hitherto unknown proarrhythmic effect of adenosine. Adenosine was administered on account of supraventricular tachycardia and the undesirable proarrhythmic effect was so-called "sine wave-like tachycardia" and ventricular fibrillation. Proarrhythmia was resistant to electric cardioversion and resuscitation was successful probably only after the breakdown of adenosine. The very short half-life of breakdown of this antiarrhythmic is thus useful not only for antiarrhythmic strategy but, because of the possible occurrence of rare proarrhythmias, adenosine holds a preferential position among other antiarrhythmic drugs.
在提交的病例报告中，作者描述了腺苷一种迄今未知的促心律失常作用。因室上性心动过速给予腺苷，不良的促心律失常作用为所谓的“正弦波样心动过速”和心室颤动。促心律失常对电复律有抵抗，可能仅在腺苷代谢后复苏才成功。这种抗心律失常药物极短的代谢半衰期不仅对抗心律失常策略有用，而且由于可能发生罕见的促心律失常情况，腺苷在其他抗心律失常药物中占据优先地位。
