Aho H J, Ping W, Söderström K O, Rinne A, Rinne R, Hopsu-Havu V K
Department of Pathology, University of Turku, Finland.
Am J Dermatopathol. 1995 Apr;17(2):115-25. doi: 10.1097/00000372-199504000-00002.
Acid cysteine proteinase inhibitor (ACPI, cystatin A) is normally present in squamous epithelium and dendritic cells of lymphoid follicles. Its expression is altered both in proliferative and malignant squamous epithelium and in neoplastic lymphoid follicles. The expression of ACPI in the lymphoid infiltrates of cutaneous psuedolymphomas and B-cell lymphomas was studied. Eighteen pseudolymphomas from 15 patients were divided into three groups according to the proportion of B and T lymphocytes. The B-cell-type lesions with well-developed follicles and germinal centers showed a pronounced ACPI expression in dendritic cells. Varying amounts of ACPI-positive cells were present in the mixed B- and T-cell-type and also in the T-cell-type lesions. The labeled cell population was distinct from the factor XIIIa-positive dermal dendrocytes, S-100-positive histiocytes, and HAM 56-positive histiocytes. Malignant lymphomas contained a few haphazardly arranged ACPI-positive cells with short dendrites and granular cytoplasm. It was concluded that follicular dendritic cells can be reliably labeled with ACPI antiserum in cutaneous pseudolymphomas. The structure and distribution of ACPI-containing cells in malignant cutaneous B-cell lymphomas is altered when compared with pseudolymphomas.
酸性半胱氨酸蛋白酶抑制剂（ACPI，胱抑素A）通常存在于鳞状上皮和淋巴滤泡的树突状细胞中。其表达在增殖性和恶性鳞状上皮以及肿瘤性淋巴滤泡中均发生改变。对皮肤假性淋巴瘤和B细胞淋巴瘤淋巴浸润中ACPI的表达进行了研究。将15例患者的18个假性淋巴瘤根据B和T淋巴细胞的比例分为三组。具有发育良好的滤泡和生发中心的B细胞型病变在树突状细胞中显示出明显的ACPI表达。在混合B和T细胞型以及T细胞型病变中存在不同数量的ACPI阳性细胞。标记的细胞群体与因子XIIIa阳性真皮树突状细胞、S-100阳性组织细胞和HAM 56阳性组织细胞不同。恶性淋巴瘤含有一些排列杂乱的ACPI阳性细胞，其具有短树突和颗粒状细胞质。得出的结论是，在皮肤假性淋巴瘤中，滤泡树突状细胞可用ACPI抗血清可靠标记。与假性淋巴瘤相比，恶性皮肤B细胞淋巴瘤中含ACPI细胞的结构和分布发生了改变。
