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Cutaneous necrosis and multinucleate epidermal cells associated with intravenous phenytoin.

作者信息

Hunt S J

机构信息

Division of Dermatology, UCSD Medical Center, San Diego, California 92103, USA.

出版信息

Am J Dermatopathol. 1995 Aug;17(4):399-402. doi: 10.1097/00000372-199508000-00017.

DOI:10.1097/00000372-199508000-00017
PMID:8600807
Abstract

A 23-year-old white man experienced burning pain up his right forearm while receiving phenytoin intravenously in the dorsal wrist. Swelling occurred, followed a few days later by an erythematous eruption that eventuated in superficial skin sloughing. The histopathology of two right forearm biopsies, taken a few days apart 3 to 4 weeks after the infusion, was characterized by partial epidermal necrosis and frequent multinucleate keratinocytes. Localized cutaneous reactions to phenytoin and the occurrence of multinucleate epidermal cells in inflammatory skin disease are reviewed.

摘要

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