Schuller D E, Goodman J H, Mountain R E, Brown B L, Frank J E, Ervin-Miller K J
J Craniofac Surg. 1995 Jan;6(1):69-74. doi: 10.1097/00001665-199501000-00017.
The indications for skull base tumor surgery have increased in recent years primarily because of improving surgical techniques and adjunctive treatment modalities. In this article we review current and future adjunctive treatment for cranial base malignancies. Surgically clear tumor margins are often difficult to achieve in skull base surgery because of unacceptable morbidity to surrounding structures. Current phase I and II trials of adjunctive radiation and chemotherapy are discussed. Future advances in radiation therapy and chemotherapy are introduced.
近年来，颅底肿瘤手术的适应证有所增加，这主要归功于手术技术的改进和辅助治疗方式的进步。在本文中，我们回顾了颅底恶性肿瘤当前及未来的辅助治疗方法。由于对周围结构造成不可接受的损伤，在颅底手术中往往难以实现手术切缘肿瘤清除。文中讨论了当前辅助放疗和化疗的I期和II期试验。还介绍了放疗和化疗未来的进展。
