小鼠粉红眼稀释（p）位点36个突变的分子分析。
Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus.
作者信息
Johnson D K, Stubbs L J, Culiat C T, Montgomery C S, Russell L B, Rinchik E M
机构信息
Biology Division, Oak Ridge National Laboratory, Tennessee 37831-8077, USA.
出版信息
Genetics. 1995 Dec;141(4):1563-71. doi: 10.1093/genetics/141.4.1563.
Abstract
Thirty-six radiation- or chemically induced homozygous-lethal mutations at the p locus in mouse chromosome 7 have been analyzed at 17 loci defined by molecular probes to determine the types of lesions, numbers of p-region markers deleted or rearranged, regions of overlap of deletion mutations, and genetic distances between loci. A linear deletion map of the [Myod1, Ldh3]-[Snrpn, Znf127] region has been constructed from the molecular analyses of the p-locus deletions. The utility of these deletions as tools for the isolation and characterization of the genes specifying the neurological, reproductive, and developmental phenotypes genetically mapped to this region will grow as more detailed molecular analyses continue.
摘要
对小鼠7号染色体p位点上36个辐射或化学诱导的纯合致死突变进行了分析，这些突变位于由分子探针定义的17个位点，以确定损伤类型、缺失或重排的p区域标记数量、缺失突变的重叠区域以及位点之间的遗传距离。通过对p位点缺失的分子分析，构建了[Myod1, Ldh3]-[Snrpn, Znf127]区域的线性缺失图谱。随着更详细的分子分析不断进行，这些缺失作为分离和鉴定在遗传上定位于该区域的神经、生殖和发育表型相关基因的工具，其效用将会增加。
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