Lee Y S
Department of Pathology, National University of Singapore, Republic of Singapore.
Int J Gynecol Pathol. 1995 Apr;14(2):119-24. doi: 10.1097/00004347-199504000-00005.
The p53 expression of normal trophoblasts (11 cases), partial moles (11 cases), complete moles (19 cases), and gestational choriocarcinoma (eight cases) were studied. We found that p53 is frequently expressed in gestational choriocarcinoma and in hydatidiform moles (mainly cytotrophoblasts), whereas syncytiotrophoblasts are generally spared. This finding supports the view that p53 expression is a reflection of proliferative capacity of cells rather than an indicator of neoplastic or malignant transformation. The greater p53 expression observed in complete moles as compared with partial moles is in keeping with the more pronounced trophoblastic hyperplasia and proliferative activity of complete moles. More interesting was the observation that p53 expression was also noted in normal trophoblasts, secretory endometrial glands, and decidual cells of the stroma. Therefore, it appears that the immunohistochemical expression of p53 can occur in a variety of situations, including neoplastic, proliferative, and nonproliferative conditions. Although p53 mutations are often the basis of excessive accumulation of mutant p53 protein in malignancies, other mechanisms may be involved in nonneoplastic conditions. These findings emphasize the need for caution in the interpretation of immunohistochemical expression of p53 protein.
研究了11例正常滋养层细胞、11例部分性葡萄胎、19例完全性葡萄胎及8例妊娠性绒毛膜癌的p53表达情况。我们发现p53在妊娠性绒毛膜癌和葡萄胎（主要是细胞滋养层细胞）中经常表达，而合体滋养层细胞通常不受影响。这一发现支持了p53表达反映细胞增殖能力而非肿瘤性或恶性转化指标的观点。与部分性葡萄胎相比，完全性葡萄胎中观察到的p53表达更高，这与完全性葡萄胎中更明显的滋养层细胞增生和增殖活性一致。更有趣的是，在正常滋养层细胞、分泌期子宫内膜腺体及基质蜕膜细胞中也观察到了p53表达。因此，似乎p53的免疫组化表达可出现在多种情况中，包括肿瘤性、增殖性和非增殖性情况。虽然p53突变常常是恶性肿瘤中突变p53蛋白过度积累的基础，但在非肿瘤性情况下可能涉及其他机制。这些发现强调了在解释p53蛋白免疫组化表达时需要谨慎。
