Yamakado M
Department of Anatomy, Jichi Medical School, Tochigi, Japan.
Neurosci Res. 1995 Nov;23(4):399-413. doi: 10.1016/0168-0102(95)00969-Z.
The disposition of the facial vibrissae of the mouse is represented as a matrix-like array of cell aggregates in rows and columns at every station of the whisker-to-barrel pathway. In order to evaluate the role of each station in this pathway, lesions were made in the facial vibrissae of the mystacial group on P0-P3, and the animals were sacrificed on P8. The effects of the lesions on the cell aggregates in the array were analyzed by using cytochrome oxidase and gallocyanin cell-staining methods. Division of cell aggregates in the array was controlled by row basis interactions through the pathway up to the cerebral cortex. In this organization, affected cell aggregates which corresponded to the damaged vibrissae were eliminated and/or fused together in the array of the thalamic relay nucleus. On the basis of thalamic modification, the final array of cell aggregates was remodelled in the cerebral cortex. In contrast, affected cell aggregates remained degenerative spaces at the original sites in the array in relation to the damaged vibrissae in the brain stem trigeminal nuclear complex. These results indicate that a protoframework with row basis orientation for the division of cell aggregates is prepared in every station of the pathway at the time of lesioning, and adjustment of subcortical alterations in the thalamic relay nucleus is a decisive process to let the cerebral cortex remodel the topographic array of cell aggregates.
小鼠面部触须的分布在触须到桶状皮层通路的每个位点都呈现为细胞聚集体的矩阵状排列，呈行和列分布。为了评估该通路中每个位点的作用，在出生后0至3天对触须组的面部触须进行损伤，并在出生后第8天处死动物。通过使用细胞色素氧化酶和胆青素细胞染色方法分析损伤对阵列中细胞聚集体的影响。阵列中细胞聚集体的划分通过该通路直至大脑皮层的逐行相互作用来控制。在这种组织方式中，与受损触须相对应的受影响细胞聚集体在丘脑中继核的阵列中被消除和/或融合在一起。基于丘脑的改变，细胞聚集体的最终阵列在大脑皮层中重新塑造。相比之下，在脑干三叉神经核复合体中，与受损触须相关的受影响细胞聚集体在阵列的原始位点仍保持退化空间。这些结果表明，在损伤时，通路的每个位点都准备了一个具有逐行方向的细胞聚集体划分的原框架，丘脑中继核中皮层下改变的调整是使大脑皮层重塑细胞聚集体地形阵列的决定性过程。
