Babkowski R C, Wilbur D C, Rutkowski M A, Facik M S, Bonfiglio T A
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, New York 14642, USA.
Am J Clin Pathol. 1996 Apr;105(4):403-10. doi: 10.1093/ajcp/105.4.403.
Use of new endocervical cytologic sampling devices has correlated with increased numbers of cases showing endocervical "atypia." To ascertain the potential causes, a cytologic and histologic correlative study of the normal endocervical canal was undertaken. Hysterectomy specimens from 25 patients with no history of cervical disease were used. The anterior and posterior endocervical canals were divided into three equal sections. Each of the sections of the anterior canal were sampled cytologically, with the corresponding posterior canal processed for histology. Endocervical gland number, depth, and cellular crowding were most pronounced in the middle third of the canal. Tubal metaplasia (present in 100% of cases) was most prominent in the upper third. The most cellular cytologic samples were obtained from the middle third. "Atypical" endocervical groups were most commonly identified in the upper third. The normal topography of the endocervical canal, with sampling of the upper regions by newly utilized devices, may account for the increase in samples showing cytologic patterns that mimic endocervical neoplasia.
使用新的宫颈管细胞学采样设备与显示宫颈管“异型性”的病例数量增加相关。为了确定潜在原因，对正常宫颈管进行了细胞学和组织学相关性研究。使用了25例无宫颈疾病病史患者的子宫切除标本。宫颈管前、后部分分为三个相等的节段。对前半部分的每个节段进行细胞学采样，后半部分相应节段进行组织学处理。宫颈管腺体数量、深度和细胞拥挤在管的中三分之一处最为明显。输卵管化生（100%的病例中存在）在上三分之一处最为突出。细胞最多的细胞学样本取自中三分之一处。“非典型”宫颈管组最常见于上三分之一处。宫颈管的正常形态，以及新使用的设备对上段区域的采样，可能是显示模拟宫颈管肿瘤细胞学模式的样本增加的原因。
