von Burg R, Landry T
J Pharm Pharmacol. 1976 Jul;28(7):548-51. doi: 10.1111/j.2042-7158.1976.tb02792.x.
Methylmercury at bath concentration of 2 X 10(-5) M was capable of inhibiting muscular contractions of the isolated rat phrenic-nerve hemidiaphragm preparation. At the height of inhibition, nerve action potential could still be recorded and the muscles continued to respond to direct stimulation. The inhibition was not reversible with L-cysteine or D-penicillamine but limited protection was possible by prior treatment with (+)-tubocurarine. Treatment of frog rectus muscles with methylmercury (0-2 mM for 15 min) resulted in a shift to the right of 1 log unit in the dose response curve to acetylcholine and a reduction in the maximum response of the tissue. The observed inhibitory action of methylmercury on neuromuscular transmission may be explained by an action on the disulphide bond believed to be present on a cholinergic receptor.
浴槽浓度为2×10⁻⁵ M的甲基汞能够抑制离体大鼠膈神经半膈肌标本的肌肉收缩。在抑制高峰时，仍可记录到神经动作电位，且肌肉仍能对直接刺激产生反应。L-半胱氨酸或D-青霉胺不能使这种抑制作用逆转，但预先用筒箭毒碱处理可提供一定程度的保护。用甲基汞（0 - 2 mM，处理15分钟）处理蛙腹直肌，导致对乙酰胆碱的剂量反应曲线向右移动1个对数单位，且组织的最大反应降低。观察到的甲基汞对神经肌肉传递的抑制作用，可能是由于其作用于胆碱能受体上据信存在的二硫键。
