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长期营养不良及随后恢复过程中大鼠的生长和骨骼发育

Growth and skeletal development of the rat during prolonged undernutrition and subsequent rehabilitation.

作者信息

McAnulty P A

出版信息

Acta Anat (Basel). 1977;98(1):39-51. doi: 10.1159/000144777.

DOI:10.1159/000144777
PMID:860632
Abstract

Male rats of 150 g body weight were given restricted amounts of their normal diet up to the age of 85 weeks, such that they showed no significant change in body weight. They were then rehabilitated by allowing them unlimited access to the normal diet. During rehabilitation, the experimental rats reached a maximum body weight that was only 70% of that normally attained. Body length, however, exhibited better recovery, the experimental animals achieving 96% of the normal body length. The skeleton continued to grow during the first 7 weeks of undernutrition, but thereafter only the caudal half of the pelvic girdle continued to grow. On rehabilitation all skeletal dimensions increased, and all eventually reached the normal range of mature skeletal dimensions. Although the pelvic girdle returned to a normal size, it still manifested some alterations in shape.

摘要

150克体重的雄性大鼠在85周龄前给予限量的正常饮食,使其体重无显著变化。然后让它们自由进食正常饮食进行恢复。恢复期间,实验大鼠达到的最大体重仅为正常体重的70%。然而,体长恢复得更好,实验动物达到了正常体长的96%。在营养不良的前7周,骨骼继续生长,但此后只有骨盆带的后半部分继续生长。恢复后,所有骨骼尺寸都增加了,最终都达到了成熟骨骼尺寸的正常范围。虽然骨盆带恢复到了正常大小,但形状仍有一些改变。

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引用本文的文献

1
The effects of a lengthy period of undernutrition on the skeletal growth of rats.长期营养不良对大鼠骨骼生长的影响。
J Anat. 1985 Aug;141:53-64.