Kronenberg R S, Drage C W, Stevenson J E
Am J Med. 1977 May;62(5):772-6. doi: 10.1016/0002-9343(77)90882-8.
We measured hypoxic and hypercapnic ventilatory drive in a 64 year old woman with acute respiratory failure, congestive heart failure and obesity when she was in remission. She had a ventilatory response to carbon dioxide (CO2) comparable to that in six obese women without hypoventilation but no ventilatory response to hypoxia or to vital capacity breaths of 15 per cent CO2 in N2. Following weight loss, her ventilatory response to CO2 increased but hypoxic ventilatory response to CO2 increased but hypoxic ventilatory drive remained absent. These findings indicate that attenuation of hypoxic ventilatory drive caused by loss of peripheral chemoreceptor function can be a predisposing factor in the development of acute respiratory failure associated with obesity.
我们在一名64岁患有急性呼吸衰竭、充血性心力衰竭和肥胖症的女性病情缓解期测量了其低氧和高碳酸血症通气驱动。她对二氧化碳（CO₂）的通气反应与六名无通气不足的肥胖女性相当，但对低氧或对含15% CO₂的氮气中的肺活量呼吸无通气反应。体重减轻后，她对CO₂的通气反应增强，但对低氧的通气驱动仍然缺乏。这些发现表明，外周化学感受器功能丧失导致的低氧通气驱动减弱可能是肥胖相关急性呼吸衰竭发生的一个易感因素。
