青少年肺脏的产甲胎蛋白鳞状细胞癌
AFP-producing squamous cell carcinoma of the lung in an adolescent.
作者信息
Asamura H, Nakayama H, Kondo H, Tsuchiya R, Ono R, Noguchi M, Yoda H, Naruke T
机构信息
Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
出版信息
Jpn J Clin Oncol. 1996 Apr;26(2):103-6. doi: 10.1093/oxfordjournals.jjco.a023181.
We report a case of primary lung cancer in a 16-year-old boy. A histologic diagnosis of squamous cell carcinoma was made by bronchoscopic biopsy before surgery. The serum alphafetoprotein (AFP) level was markedly elevated at 193 ng/dl. Preoperative and postoperative evaluation revealed no evidence of scrotal mass. We performed right pneumonectomy with combined resection of the invaded portion of the left atrium under extracorporeal circulation. Despite the rapid improvement in the patient's general condition after surgery, the AFP level continued to increase without a transient decrease and reached 3160 ng/ml on the 23rd postoperative day. When the patient was readmitted because of dyspnea and headache on the 36th postoperative day, hypercalcemia of 13.9 mg/dl was noted, and this was resistant to subsequent treatment. The patient died on the 46th postoperative day.
我们报告一例16岁男孩的原发性肺癌。术前经支气管镜活检做出鳞状细胞癌的组织学诊断。血清甲胎蛋白（AFP）水平显著升高，达193 ng/dl。术前和术后评估均未发现阴囊肿物迹象。我们在体外循环下进行了右肺切除术，并联合切除了左心房受侵部分。尽管术后患者的一般状况迅速改善，但AFP水平持续升高，未出现短暂下降，术后第23天达到3160 ng/ml。术后第36天，患者因呼吸困难和头痛再次入院时，发现血钙过高，为13.9 mg/dl，且后续治疗对此无效。患者于术后第46天死亡。
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