Ittmann M M
Department of Pathology, New York University School of Medicine, Kaplan Comprehensive Cancer Center, New York, USA.
Prostate. 1996 May;28(5):275-81. doi: 10.1002/(SICI)1097-0045(199605)28:5<275::AID-PROS1>3.0.CO;2-B.
Loss of heterozygosity (LOH) at chromosomal loci has been associated with the presence of tumor suppressor genes at the deleted loci. Twenty-six clinically localized, Stage B prostate carcinomas were analyzed for LOH on chromosomes 10 and 17 using microsatellite markers. Two of 26 carcinomas showed LOH on 17p while one showed LOH on 17q. Chromosome 10 showed a complex pattern of LOH with monosomy (1 case), LOH on 10p (1 case), proximal 10q (1 case) and distal 10q (2 cases). Overall 29% of informative cases showed LOH on chromosome 10. These results are consistent with the presence of a tumor suppressor for prostate cancer on 17p and multiple tumor suppressor genes on chromosome 10.
染色体位点的杂合性缺失（LOH）与缺失位点处肿瘤抑制基因的存在有关。使用微卫星标记对26例临床局限性B期前列腺癌进行了10号和17号染色体上LOH的分析。26例癌中有2例在17p显示LOH，1例在17q显示LOH。10号染色体显示出复杂的LOH模式，包括单体型（1例）、10p上的LOH（1例）、10q近端（1例）和10q远端（2例）。总体而言，29%的信息性病例在10号染色体上显示LOH。这些结果与17p上存在前列腺癌肿瘤抑制基因以及10号染色体上存在多个肿瘤抑制基因一致。
