Lopez M J, Porter K A
Department of Surgery, Tufts University School of Medicine, Boston, Massachusetts, USA.
Surg Clin North Am. 1996 Apr;76(2):231-42. doi: 10.1016/s0039-6109(05)70436-9.
Prophylactic mastectomy has a role in preventing breast cancer in the woman at high risk. The rare indications for this operation are based on genetic and histologic factors that affect relative or cumulative risk. Evaluation of women at high risk must draw on multidisciplinary expertise, including genetic counseling. If prophylactic mastectomy is recommended, skin-sparing total mastectomy (not subcutaneous) with autogenous tissue reconstruction is the preferred approach.
预防性乳房切除术在预防高危女性患乳腺癌方面具有一定作用。该手术的罕见适应症基于影响相对风险或累积风险的遗传和组织学因素。对高危女性的评估必须借助多学科专业知识，包括遗传咨询。如果建议进行预防性乳房切除术，保留皮肤的全乳切除术（而非皮下乳房切除术）并采用自体组织重建是首选方法。
