Price B A, Cumberland N S, Clark C L, Pockley A G, Wood R F
Department of Surgical Sciences, Clinical Sciences Centre, Northern General Hospital, Sheffield, United Kingdom.
Transplantation. 1996 Feb 27;61(4):649-51. doi: 10.1097/00007890-199602270-00022.
An overgrowth of pathogenic organisms occurs following rat heterotopic small bowel transplantation. This study assessed whether the bacterial microflora return to normal following subsequent orthotopic transposition of the graft. After 14 days the heterotopic graft was placed into continuity following resection of 15 cm of the host midintestinal loop. Quantitative and qualitative analyses of the intraluminal bacteria were performed studying the resected host intestine, the heterotopic graft at 14 days, and the graft 14 days after transposition. A group of normal rats were used as controls. An overgrowth of Staphylococcus epidermidis evident in the heterotopic graft at 14 days returned to a more normal bacterial profile following orthotopic transposition. These findings suggest that early interposition of a small bowel graft into an orthotopic position may prevent an alteration in the small bowel ecology toward potentially pathogenic organisms capable of translocation.
大鼠异位小肠移植后会出现致病微生物过度生长的情况。本研究评估了在随后将移植物原位转位后，细菌微生物群是否会恢复正常。14天后，在切除15厘米的宿主中肠袢后，将异位移植物连接起来。对腔内细菌进行了定量和定性分析，研究了切除的宿主肠段、14天时的异位移植物以及转位14天后的移植物。一组正常大鼠用作对照。14天时异位移植物中明显的表皮葡萄球菌过度生长在原位转位后恢复到更正常的细菌谱。这些发现表明，早期将小肠移植物置于原位可能会防止小肠生态向具有移位能力的潜在致病生物体发生改变。
