Kuo P C, Petersen J, Semba C, Alfrey E J, Dafoe D C
Department of Surgery, Stanford University Medical Center, California 94305, USA.
Transplantation. 1996 Feb 27;61(4):652-4. doi: 10.1097/00007890-199602270-00023.
Use of iodinated contrast for vascular imaging can be associated with nephrotoxicity and hypersensitivity reactions. Renal injury following conventional angiography is more likely to manifest in the setting of preexisting renal dysfunction. In the setting of suboptimal renal allograft function, these considerations are particularly relevant. Recently, CO2 has received attention as a nontoxic, injectable, rapidly absorbed gas that is a cost-effective alternative to standard contrast agents in high-risk patients, such as renal transplant recipients. We report the clinical course of a patient with transplant renal artery stenosis and a serum creatinine of 2.8 mg/dl who has successfully undergone angiography and percutaneous transluminal angioplasty using CO2 as the sole contrast agent. This case illustrates the potential use for CO2 as a contrast agent for vascular imaging in patients with suboptimal renal function who require definitive vascular imaging or therapy.
使用碘化造影剂进行血管成像可能会导致肾毒性和过敏反应。传统血管造影术后的肾损伤在已有肾功能不全的情况下更易表现出来。在肾移植功能欠佳的情况下，这些因素尤为重要。最近，二氧化碳作为一种无毒、可注射、吸收迅速的气体受到关注，对于高危患者（如肾移植受者）而言，它是一种比标准造影剂更具成本效益的替代品。我们报告了一名移植肾动脉狭窄且血清肌酐为2.8mg/dl的患者的临床过程，该患者成功接受了以二氧化碳作为唯一造影剂的血管造影和经皮腔内血管成形术。此病例说明了二氧化碳作为造影剂在需要明确血管成像或治疗的肾功能欠佳患者进行血管成像中的潜在用途。
