Inoue S
Department of Environmental Medicine and Informatics, Graduate School of Environmental Earth Science, Hokkaido University, Japan.
Gan To Kagaku Ryoho. 1996 Jan;23(2):191-201.
Data resulting from new insights into targets for cancer chemotherapy have been stored after the educational symposium entitled "Novel Targets for Cancer Therapy" was held at the 27th Annual Meeting of the American Society of Clinical Oncology in 1991. Novel targets for cancer chemotherapy, which have been found or assessed to be useful after the meeting, are summarized. The contents are as follows: 1) inhibitors of signal transduction pathway, 2) inducers of apoptosis and/or differentiation, 3) agents acting on DNA directly and indirectly, 4) inhibitors of telomerase, 5) agents acting on cytoplasmic microorgans, 6) inhibitors of cytoplasmic metabolism, 7) modulators of multidrug resistance, and 8) unknown or complex targets of drug action. Targets described in each passage may be applicable to the development of new anticancer agents. Agents acting on the targets have been optionally chosen and listed. The significance of important targets and agents in cancer chemotherapy is described in more detail.
在1991年美国临床肿瘤学会第27届年会上举行了题为“癌症治疗的新靶点”的教育研讨会之后，有关癌症化疗靶点新见解所产生的数据已被存储。总结了在该会议之后发现或评估为有用的癌症化疗新靶点。内容如下：1）信号转导途径抑制剂；2）凋亡和/或分化诱导剂；3）直接和间接作用于DNA的药物；4）端粒酶抑制剂；5）作用于细胞质细胞器的药物；6）细胞质代谢抑制剂；7）多药耐药调节剂；8）药物作用的未知或复杂靶点。每一段中描述的靶点可能适用于新型抗癌药物的开发。已任选并列出了作用于这些靶点的药物。更详细地描述了癌症化疗中重要靶点和药物的意义。
