Bak J, Olsson Y, Grimelius L, Spännare B
Department of Pathology, University Hospital, Uppsala, Sweden.
APMIS. 1996 Mar;104(3):234-40.
A 59-year-old man presented with clinical evidence of a primary tumor of the cauda equina region. It was well circumscribed and was completely removed by neurosurgery. Routine staining showed that it had structural similarities to an ependymoma, but immunohistochemistry with antisera to synaptophysin, NSE, chromogranin-A and PGP 9.5 proved it to be a neuroendocrine tumor, i.e. a paraganglioma. We propose the use of endocrine markers in cases with tumors of the cauda equina to differentiate a paraganglioma from an ependymoma. Paragangliomas appear to have a better clinical outcome than ependymomas. Recurrence after surgery for a paraganglioma in the cauda equina region, especially if it is encapsulated, is rarely encountered.
一名59岁男性患者出现马尾区原发性肿瘤的临床证据。肿瘤边界清晰，经神经外科手术完全切除。常规染色显示其结构与室管膜瘤相似，但针对突触素、神经元特异性烯醇化酶、嗜铬粒蛋白A和PGP 9.5的抗血清免疫组化证实其为神经内分泌肿瘤，即副神经节瘤。我们建议在马尾区肿瘤病例中使用内分泌标志物来区分副神经节瘤和室管膜瘤。副神经节瘤的临床预后似乎比室管膜瘤更好。马尾区副神经节瘤手术后复发，尤其是肿瘤有包膜的情况下，很少见。
