卡比多巴给药对人体尿钠排泄的影响。多巴胺是一种肾内利钠激素吗？
The effect of carbidopa administration on urinary sodium excretion in man. Is dopamine an intrarenal natriuretic hormone?
作者信息
Ball S G, Lee M R
出版信息
Br J Clin Pharmacol. 1977 Apr;4(2):115-9. doi: 10.1111/j.1365-2125.1977.tb00681.x.
Abstract
1 Carbidopa, a known inhibitor of the peripheral conversion of dopa to dopamine, was given to six normal volunteers to examine the effect of interference with dopamine synthesis on urinary sodium excretion. 2 On the first day of administration, carbidopa caused a significant fall not only in urinary dopamine excretion (P less than 0.01) but also in urinary sodium excretion (P less than 0.05). 3 A highly significant correlation was also found between mean sodium excretion and mean dopamine excretion in the days prior to and during carbidopa administration (r = 0.617, P less than 0.001; 4 = 0.764, P less than 0.001 respectively). 4 The significance of these findings is discussed and it is proposed that dopamine may be an important intrarenal natriuretic hormone.
摘要
- 卡比多巴是一种已知的多巴外周转化为多巴胺的抑制剂，给予6名正常志愿者以研究干扰多巴胺合成对尿钠排泄的影响。2. 在给药的第一天，卡比多巴不仅使尿多巴胺排泄显著下降（P<0.01），而且使尿钠排泄也显著下降（P<0.05）。3. 在卡比多巴给药前及给药期间，平均钠排泄与平均多巴胺排泄之间也发现高度显著的相关性（r分别为0.617，P<0.001；0.764，P<0.001）。4. 讨论了这些发现的意义，并提出多巴胺可能是一种重要的肾内利钠激素。
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The effect of carbidopa administration on urinary sodium excretion in man. Is dopamine an intrarenal natriuretic hormone?卡比多巴给药对人体尿钠排泄的影响。多巴胺是一种肾内利钠激素吗？
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