Camplejohn R S, Schultze B, Maurer W
Br J Cancer. 1977 May;35(5):546-56. doi: 10.1038/bjc.1977.88.
[3H]-TdR and [3]-udR labelling indices and mitotic indices were followed in tumour-bearing mice after application of either 5-fluorouracil (FU) alone or of FU followed by cold TdR infusion. With FU alone, accumulation of cells at the beginning of S was found, but there was no indication of a synchronous passage of the accumulated cells further round the cycle. When FU injection was followed by cold TdR infusion, a synchronous passage of the accumulated cells through the cycle was observed. However, there was a large variation in the response of individual mice to this treatment.
在荷瘤小鼠中，单独应用5-氟尿嘧啶（FU）或FU后进行冷胸苷输注后，跟踪观察[3H]-胸腺嘧啶核苷（TdR）和[3]-尿嘧啶核苷（udR）标记指数以及有丝分裂指数。单独使用FU时，发现细胞在S期开始时积累，但没有迹象表明积累的细胞在细胞周期中进一步同步通过。当FU注射后进行冷TdR输注时，观察到积累的细胞在细胞周期中同步通过。然而，个体小鼠对这种治疗的反应存在很大差异。
