大鼠磷酸核糖焦磷酸合成酶相关蛋白39的启动子区域
Promoter region of the rat phosphoribosylpyrophosphate synthetase-associated protein 39.
作者信息
Ishizuka T, Sawa K, Kita K, Ino H, Sonoda T, Suzuki N, Tatibana M
机构信息
Department of Biochemistry, Chiba University, School of Medicine, Japan.
出版信息
Biochim Biophys Acta. 1996 Apr 10;1306(1):34-7. doi: 10.1016/0167-4781(95)00226-x.
The 5' region of the 39-kDa rat phosphoribosylpyrophosphate synthetase-associated protein (PAP39) gene was isolated and sequenced. The promoter region of the rat PAP39 is GC-rich and contains potential binding sites for regulatory factors. Its promoter activity was demonstrated by transfection of the promoter region in fusion with the chloramphenicol acetyltransferase gene into rat pheochromocytoma PC12 cell.
分离并测序了39 kDa大鼠磷酸核糖焦磷酸合成酶相关蛋白（PAP39）基因的5'区域。大鼠PAP39的启动子区域富含GC，并且含有调控因子的潜在结合位点。通过将与氯霉素乙酰转移酶基因融合的启动子区域转染到大鼠嗜铬细胞瘤PC12细胞中，证明了其启动子活性。
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