大鼠41 kDa磷酸核糖焦磷酸合成酶相关蛋白的cDNA克隆与测序显示，其与催化亚基和39 kDa相关蛋白具有高度同源性。
Cloning and sequencing of rat cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein has a high homology to the catalytic subunits and the 39-kDa associated protein.
作者信息
Sonoda T, Ishizuka T, Kita K, Ishijima S, Tatibana M
机构信息
Department of Biochemistry, Chiba University School of Medicine, Japan.
出版信息
Biochim Biophys Acta. 1997 Jan 3;1350(1):6-10. doi: 10.1016/s0167-4781(96)00190-x.
Rat liver phosphoribosylpyrophosphate synthetase is a complex aggregate of 34-kDa catalytic subunits (PRS I and II) and 39- and 41-kDa associated proteins (PAP39 and 41). When the rat cDNA encoding PAP41 was isolated, the deduced protein sequence was seen to contain 369 amino acids with a calculated molecular mass of 41130. PAP41 has a 79 and 49% identity with PAP39 and PRSs, respectively. When conservative substitutions are included, PAP41 and the three other components have a 66% homology. PAP41 shares some common features with PAP39 and the two proteins form the PAP subfamily. The mRNA of PAP41 is present in all rat tissues we examined.
大鼠肝脏磷酸核糖焦磷酸合成酶是由34 kDa催化亚基（PRS I和II）以及39 kDa和41 kDa相关蛋白（PAP39和PAP41）组成的复合聚集体。当分离出编码PAP41的大鼠cDNA时，推导的蛋白质序列显示含有369个氨基酸，计算分子量为41130。PAP41与PAP39和磷酸核糖焦磷酸合成酶的同源性分别为79%和49%。若计入保守性替代，则PAP41与其他三个组分的同源性为66%。PAP41与PAP39具有一些共同特征，这两种蛋白质构成PAP亚家族。PAP41的mRNA存在于我们检测的所有大鼠组织中。
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