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[种痘样水疱病]

[Hydroa vacciniforme].

作者信息

Pfau A, Hein R, Karrer S, Landthaler M

机构信息

Dermatologische Klinik and Poliklinik, Universität Regensburg.

出版信息

Dtsch Med Wochenschr. 1996 Apr 19;121(16):517-20. doi: 10.1055/s-2008-1043035.

Abstract

HISTORY AND CLINICAL FINDINGS

For three years, each time the day after intensive exposure to the sun a 5-year-old girl developed moderately painful erythema and blisters on uncovered parts of her body which subsequently healed with scarring. There was no increased photosensitivity among members of her family. There were numerous blisters and bullae, some of them confluent, filled with serous fluid on her back, on her arms an in the face. There were varioliform scars on the extensor surfaces of her arms.

INVESTIGATION

There were no porphyrins in red cells, serum or urine. The characteristic skin changes were reproduced on exposure to UV-A. These findings established the diagnosis of hydroa vacciniforme.

TREATMENT AND COURSE

Prolonged sun exposure was to be avoided and protective ointment was prescribed together with administration of beta-carotene, 25 mg twice daily.

CONCLUSION

In children light-induced skin changes which heal with scarring may be due to hydroa vacciniforme.

摘要

病史及临床检查结果

三年来,一名5岁女孩每次在强烈日晒后的次日,身体暴露部位都会出现中度疼痛的红斑和水疱,随后愈合并留下疤痕。其家庭成员中无光敏性增加的情况。她的背部、手臂和面部有大量水疱和大疱,部分相互融合,疱内充满浆液性液体。手臂伸侧有痘疮样疤痕。

检查

红细胞、血清及尿液中均无卟啉。暴露于紫外线A时可再现特征性皮肤改变。这些发现确立了种痘样水疱病的诊断。

治疗及病程

应避免长时间日晒,并开具了防护软膏,同时给予β-胡萝卜素,每日两次,每次25毫克。

结论

在儿童中,愈合后留有疤痕的光诱导性皮肤改变可能是种痘样水疱病所致。

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