Que F G, Gores G J
Center for Basic Research in Digestive Disease, Division of Gastroenterology and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
Gastroenterology. 1996 Apr;110(4):1238-43. doi: 10.1053/gast.1996.v110.pm8613014.
We have reviewed in a conceptual manner with appropriate scientific detail the role apoptosis plays in diseases of the gastrointestinal tract. This information should help the clinician and clinician investigator to better understand and treat gastrointestinal diseases. Future investigations in apoptosis probably will provide further insight into the cell-signaling cascades regulating apoptosis, the mechanism(s) by which Bcl-2 inhibits apoptosis, and the precise role of apoptosis in cancer initiation, promotion, and progression. We anticipate that in the future, the practicing gastroenterologist will have therapeutic strategies available to inhibit apoptosis for various gastrointestinal diseases associated with cell death and to induce apoptosis for the treatment of gastrointestinal neoplasia.
我们以概念性的方式并结合适当的科学细节，回顾了细胞凋亡在胃肠道疾病中所起的作用。这些信息应有助于临床医生和临床研究人员更好地理解和治疗胃肠道疾病。未来对细胞凋亡的研究可能会进一步深入了解调节细胞凋亡的细胞信号级联反应、Bcl-2抑制细胞凋亡的机制，以及细胞凋亡在癌症起始、促进和进展中的精确作用。我们预计，未来执业胃肠病学家将拥有治疗策略，可用于抑制与细胞死亡相关的各种胃肠道疾病中的细胞凋亡，并诱导细胞凋亡以治疗胃肠道肿瘤。
