Yang Liangjun, Li Jiali, Hu Zhipeng, Fan Xiangzhen, Cai Tiantian, Pan Huafeng
Department of Gastroenterology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China.
Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Evid Based Complement Alternat Med. 2020 Apr 26;2020:9154738. doi: 10.1155/2020/9154738. eCollection 2020.
Gastric precancerous lesions (GPLs) are an essential precursor in the occurrence and development of gastric cancer, known to be one of the most common and lethal cancers worldwide. Traditional Chinese medicine (TCM) has a positive prospect for the prevention and therapy of GPL owing to several advantages including a definite curative effect, fewer side effects compared to other treatments, multiple components, and holistic regulation. Despite these characteristic advantages, the mechanisms of TCM in treating GPL have not been fully elucidated. In this review, we summarize the current knowledge with respect to herbal formulations and the therapeutic mechanisms of TCM active ingredients for GPL. This paper elaborates on the mechanisms of TCM underlying the prevention and treatment of GPL, specifically those that are linked to anti-, anti-inflammation, antiproliferation, proapoptotic, antioxidation, antiglycolytic, and antiangiogenesis effects.
胃癌前病变（GPLs）是胃癌发生和发展过程中的重要前驱病变，胃癌是全球最常见且致命的癌症之一。由于疗效确切、与其他治疗方法相比副作用较少、成分多样以及整体调节等诸多优势，传统中医（TCM）在GPL的预防和治疗方面具有积极的前景。尽管具有这些独特优势，但中医治疗GPL的机制尚未完全阐明。在本综述中，我们总结了目前关于中药复方以及中医活性成分治疗GPL的作用机制的知识。本文详细阐述了中医预防和治疗GPL的机制，特别是那些与抗[此处原文缺失相关具体内容]、抗炎、抗增殖、促凋亡、抗氧化、抗糖酵解和抗血管生成作用相关的机制。
