Liang R, Todd D, Ho F C
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.
Hematol Oncol. 1996 Mar;14(1):1-6. doi: 10.1002/(SICI)1099-1069(199603)14:1<1::AID-HON555>3.0.CO;2-Y.
This study is aimed to define the clinical characteristics, treatment of outcome and independent prognostic factors of 144 patients with T- and 357 B-cell non-Hodgkin's lymphomas. Entities with well-defined immunophenotype and clinical characteristics were excluded. Patients with T-cell tumours were younger. T-immunophenotype was associated with more advanced disease and presence of B symptoms. They were also less likely to have bulky disease. Primary nasal lymphomas were usually T-cell while lymphomas arising from the gastrointestinal tract and Waldeyer's ring were mostly B-cell. On univariate analysis, T-immunophenotype was associated with lower CR rate, higher relapse rate and inferior overall survival. On the other hand, multivariate analysis revealed that advanced stage, presence of B symptoms, advanced age, high serum lactate dehydrogenase level and use of non-doxorubicin-containing regimens for induction were associated with poor prognosis. Immunophenotype was not a significant independent prognostic factor.
本研究旨在明确144例T细胞和357例B细胞非霍奇金淋巴瘤患者的临床特征、治疗结局及独立预后因素。具有明确免疫表型和临床特征的淋巴瘤实体被排除在外。T细胞肿瘤患者较为年轻。T免疫表型与疾病进展程度更高及B症状的出现相关。他们出现大包块病变的可能性也较小。原发性鼻淋巴瘤通常为T细胞型，而起源于胃肠道和瓦尔代尔环的淋巴瘤大多为B细胞型。单因素分析显示，T免疫表型与较低的完全缓解率、较高的复发率及较差的总生存率相关。另一方面，多因素分析显示，晚期、B症状的出现、高龄、血清乳酸脱氢酶水平升高及诱导治疗使用不含多柔比星的方案与预后不良相关。免疫表型不是一个显著的独立预后因素。
