Schieffer B, Paxton W G, Marrero M B, Bernstein K E
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 03022, USA.
Hypertension. 1996 Mar;27(3 Pt 2):476-80. doi: 10.1161/01.hyp.27.3.476.
Angiotensin II is the major effector peptide of the renin-angiotensin system. In addition to its vasoconstrictor activity, angiotensin II stimulates smooth muscle cell growth in arterial hypertension and in models of vascular injury. The angiotensin II type 1 receptor is a seven-transmembrane receptor and is responsible for virtually all the physiological actions of angiotensin II. This class of receptor signals in part through its association with heterotrimeric G proteins. A newly developed concept for guanine nucleotide protein-coupled receptors is the activation of intracellular second-messenger proteins via tyrosine phosphorylation. For instance, angiotensin II stimulates the rapid tyrosine phosphorylation and activation of phospholipase C-gamma1. Also, angiotensin II stimulates the tyrosine phosphorylation of Janus kinases. In this review, we discuss early signaling events induced by angiotensin II with an emphasis on tyrosine phosphorylation. Understanding the importance of tyrosine phosphorylation in the signaling pathways of the angiotensin II type 1 receptor may lead to new treatment modalities for cardiovascular disease.
血管紧张素II是肾素-血管紧张素系统的主要效应肽。除了其血管收缩活性外，血管紧张素II在动脉高血压和血管损伤模型中还能刺激平滑肌细胞生长。血管紧张素II 1型受体是一种七跨膜受体，几乎负责血管紧张素II的所有生理作用。这类受体部分通过与异源三聚体G蛋白结合来传递信号。鸟嘌呤核苷酸蛋白偶联受体的一个新发展概念是通过酪氨酸磷酸化激活细胞内第二信使蛋白。例如，血管紧张素II刺激磷脂酶C-γ1的快速酪氨酸磷酸化和激活。此外，血管紧张素II刺激Janus激酶的酪氨酸磷酸化。在本综述中，我们讨论血管紧张素II诱导的早期信号事件，重点是酪氨酸磷酸化。了解酪氨酸磷酸化在血管紧张素II 1型受体信号通路中的重要性可能会带来心血管疾病的新治疗方法。
