Bertrand S, Cheix F
Biomedicine. 1977 Mar;27(2):82-4.
The authors looked for the percentage od sex chromatin in benign (73 cases) and malignant (131 cases) female mammary tumors. The sex chromatin was present in at least 30% of nuclei in benign tumors. On the other hand, in malignant tumors, the sex chromatin was present in 4 to 30% of nuclei in 42 cases and over 30% of nuclei in 76 cases. We observed one or two sex chromatin in the same nuclei in 12 malignant tumors. No correlation was observed between the percentage of sex chromatin and other prognostic factors : TNM (tumor, nodes, and metastasis), histological grading, nodal involvement, hormonal status. The authors also observed the survival after radical treatment. Therefore, this may raise the question of the value of the test.
作者研究了良性（73例）和恶性（131例）女性乳腺肿瘤中性染色质的百分比。良性肿瘤中至少30%的细胞核存在性染色质。另一方面，在恶性肿瘤中，42例患者的性染色质存在于4%至30%的细胞核中，76例患者的性染色质存在于超过30%的细胞核中。我们在12例恶性肿瘤的同一细胞核中观察到一或两个性染色质。未观察到性染色质百分比与其他预后因素（TNM分期、组织学分级、淋巴结受累情况、激素状态）之间存在相关性。作者还观察了根治性治疗后的生存率。因此，这可能会引发关于该检测价值的问题。
