连接蛋白32是一种存在于外周神经系统和中枢神经系统中的髓鞘相关蛋白。
Connexin32 is a myelin-related protein in the PNS and CNS.
作者信息
Scherer S S, Deschênes S M, Xu Y T, Grinspan J B, Fischbeck K H, Paul D L
机构信息
Department of Neurology, University of Pennsylvania, Philadelphia 19104-6146, USA.
出版信息
J Neurosci. 1995 Dec;15(12):8281-94. doi: 10.1523/JNEUROSCI.15-12-08281.1995.
We have examined the expression of a gap junction protein, connexin32 (Cx32), in Schwann cells and oligodendrocytes. In peripheral nerve, Cx32 is found in the paranodal myelin loops and Schmidt-Lanterman incisures of myelinating Schwann cells, and the levels of Cx32 protein and mRNA change in parallel with those of other myelin-related genes during development, Wallerian degeneration, and axonal regeneration. In the central nervous system, Cx32 is found in oligodendrocytes and their processes, but not in compact myelin, and the levels of Cx32 protein and mRNA increase during development in parallel with those of the other myelin genes. Thus, Cx32 is expressed as part of the myelinating phenotype of both Schwann cells and oligodendrocytes, indicating that this gap junction protein plays in important role in the biology of myelin-forming cells.
我们研究了缝隙连接蛋白连接蛋白32（Cx32）在施万细胞和少突胶质细胞中的表达情况。在周围神经中，Cx32存在于有髓鞘施万细胞的结旁髓鞘环和施密特-兰特尔曼切迹中，在发育、华勒氏变性和轴突再生过程中，Cx32蛋白和mRNA的水平与其他髓鞘相关基因的水平平行变化。在中枢神经系统中，Cx32存在于少突胶质细胞及其突起中，但不存在于致密髓鞘中，在发育过程中，Cx32蛋白和mRNA的水平与其他髓鞘基因的水平平行增加。因此，Cx32作为施万细胞和少突胶质细胞髓鞘形成表型的一部分而表达，表明这种缝隙连接蛋白在髓鞘形成细胞的生物学中起重要作用。
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