慢性可卡因滥用者体内血清素5-HT2受体的可用性

Serotonin 5-HT2 receptor availability in chronic cocaine abusers.

作者信息

Wang G J, Volkow N D, Logan J, Fowler J S, Schlyer D, MacGregor R R, Hitzemann R J, Gjedde A, Wolf A P

机构信息

Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA.

出版信息

Life Sci. 1995 Mar 10;56(16):PL299-303. doi: 10.1016/0024-3205(95)00090-9.

DOI:10.1016/0024-3205(95)00090-9

PMID:8614247

Abstract

Serotonin 5-HT2 receptor availability was evaluated in chronic cocaine abusers (n = 19) using positron emission tomography and F-18 N-methylspiperone and was compared to control subjects (n =19). 5-HT2 Receptor availability was measured in frontal, occipital, cingulate and orbitofrontal cortices using the ratio of the distribution volume in the region of interest to that in the cerebellum which is a function of Bmax/Kd. 5-HT2 Receptor availability was significantly higher in cingulate and orbitofrontal cortices than in other frontal regions or occipital cortex. The values were not different in normal subjects and cocaine abusers. These results did not show any changes in 5-HT2 receptor availability in cocaine abusers as compared to the control subjects.

摘要

使用正电子发射断层扫描和F-18 N-甲基螺哌隆评估了慢性可卡因滥用者（n = 19）的血清素5-HT2受体可用性，并与对照受试者（n = 19）进行了比较。使用感兴趣区域的分布体积与小脑区域的分布体积之比（这是Bmax/Kd的函数）来测量额叶、枕叶、扣带回和眶额皮质中的5-HT2受体可用性。扣带回和眶额皮质中的5-HT2受体可用性显著高于其他额叶区域或枕叶皮质。正常受试者和可卡因滥用者的数值没有差异。这些结果表明，与对照受试者相比，可卡因滥用者的5-HT2受体可用性没有任何变化。