钙超载增强糖尿病大鼠心脏缺血后心肌顿抑

Enhancement of postischemic myocardial stunning by calcium overload in hearts of diabetic rats.

作者信息

Shimabukuro M, Higa S, Shinzato T, Nagamine F, Takasu N

机构信息

Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Japan.

出版信息

Life Sci. 1996;58(15):1291-9. doi: 10.1016/0024-3205(96)00091-4.

DOI:10.1016/0024-3205(96)00091-4

PMID:8614283

Abstract

The effects of Ca2+ concentration on postischemic myocardial stunning were studied in isolated working hearts of rats with streptozotocin-induced diabetes and of age-matched control rats. During reperfusion after 10 min of ischemia, hearts from control rats showed complete recovery of cardiac function of Ca2+ concentrations of 1.25, 1.88, and 2.50 mmol/L, while the recovery of diabetic rats was decreased only at a Ca2+ concentration of 2.50 mmol/L. Although myocardial Na+ and Ca2+ concentrations were comparable between control and diabetic rats, only diabetic rats showed increases in myocardial concentration of Na+ during ischemia and Ca2+ during reperfusion at a Ca2+ concentration of 2.50 mmol/L. Results suggest that diabetic rat hearts are vulnerable to postischemic stunning via an overload of calcium.

摘要

在链脲佐菌素诱导的糖尿病大鼠和年龄匹配的对照大鼠的离体工作心脏中，研究了钙离子浓度对缺血后心肌顿抑的影响。在缺血10分钟后的再灌注期间，对照大鼠心脏在钙离子浓度为1.25、1.88和2.50 mmol/L时心脏功能完全恢复，而糖尿病大鼠仅在钙离子浓度为2.50 mmol/L时恢复有所降低。尽管对照大鼠和糖尿病大鼠的心肌钠和钙浓度相当，但只有糖尿病大鼠在钙离子浓度为2.50 mmol/L时，缺血期间心肌钠浓度和再灌注期间心肌钙浓度升高。结果表明，糖尿病大鼠心脏因钙超载而易发生缺血后顿抑。