Pronczuk A, Khosla P, Hajri T, Hayes K C
Foster Biomedical Research Laboratory, Brandeis University, Waltham, Massachusetts 02254, USA.
Lipids. 1995 Dec;30(12):1157-61. doi: 10.1007/BF02536618.
To compare the relative impact of dietary lauric acid (12:0) and palmitic acid (16:0) on plasma lipids, two fat-sensitive species, Mongolian gerbils and cebus monkeys, were fed cholesterol-free, purified diets enriched with either 12:0-rich or 16:0-rich fats, while all other fatty acids were held constant by selective blending of up to five natural fats or oils. The two gerbil diets (40 en% from fat) allowed for an 8 en% exchange between 12:0 and 16:0, and the monkey diets (31 en% from fat) allowed for 6 en% exchange between these two fatty acids. Eight gerbils received the diets for eight weeks, and 12 cebus monkeys were fed each diet in a cross-over design for up to 22 wk. Both diets resulted in similar plasma cholesterol, triglyceride, and high density lipoprotein cholesterol concentrations within each species. Additionally, separation of cebus lipoproteins by discontinuous density-gradient ultracentrifugation failed to show any dietary differences in concentration or composition of the three major lipoprotein classes (d < 1.019, 1.019-1.055, and 1.055-1.168 g/mL). Thus, in two species sensitive to manipulations in dietary fat while consuming cholesterol-free diets, 16:0 was not hypercholesterolemic relative to 12:0.
为比较膳食月桂酸（12:0）和棕榈酸（16:0）对血浆脂质的相对影响，选用两种对脂肪敏感的物种——蒙古沙鼠和卷尾猴，给它们喂食不含胆固醇的纯化饮食，这些饮食富含富含12:0或富含16:0的脂肪，同时通过选择性混合多达五种天然脂肪或油类使所有其他脂肪酸保持恒定。两种沙鼠饮食（40%能量来自脂肪）允许12:0和16:0之间进行8%能量的交换，而猴子饮食（31%能量来自脂肪）允许这两种脂肪酸之间进行6%能量的交换。八只沙鼠接受饮食八周，12只卷尾猴采用交叉设计，每种饮食喂食长达22周。两种饮食在每个物种中均导致相似的血浆胆固醇、甘油三酯和高密度脂蛋白胆固醇浓度。此外，通过不连续密度梯度超速离心分离卷尾猴脂蛋白未能显示三种主要脂蛋白类别（密度<1.019、1.019 - 1.055和1.055 - 1.168 g/mL）在浓度或组成上存在任何饮食差异。因此，在两种对膳食脂肪变化敏感且食用不含胆固醇饮食的物种中，相对于12:0，16:0不会引起高胆固醇血症。
