Lang P, Vahlensieck M, Matthay K K, Johnston J O, Rosenau W, Gooding C A, Genant H K
Department of Radiology, University of California San Francisco 94143-0628, USA.
Med Pediatr Oncol. 1996 May;26(5):329-33. doi: 10.1002/(SICI)1096-911X(199605)26:5<329::AID-MPO5>3.0.CO;2-K.
Histologic studies on resected specimen have shown that tumor neovascularity is related to prognosis and response to therapy in a variety of human neoplasms. In nine patients with osteogenic or Ewing sarcoma, we evaluated the use of magnetic resonance angiography (MRA) to assess neovascularity non-invasively in vivo and to monitor response to chemotherapy. Seven patients with osteosarcoma and two patients with Ewing sarcoma were studied before and after chemotherapy by MRA (2-D time-of-flight gradient-echo sequence, TR = 50 msec, TE = 9.5 msec, theta = 50 degrees, acquisition time 13 min). MR angiograms were assessed for chemotherapy-induced changes in neovascularity. MRA showed both feeder vessels and neovascularity. Six patients responded to chemotherapy ( > or = 90% histologic tumor necrosis). MRA demonstrated marked reduction in neovascularity in all responders. Three patients did not respond to chemotherapy ( < 90% histologic tumor necrosis). MRA demonstrated persistent or increased neovascularity in the non-responders. MRA provides a unique opportunity to study tumoral neovascularity noninvasively in vivo and helps to assess response to chemotherapy in patients with osteogenic or Ewing sarcoma. These general principles may be applicable to other human tumors.
对切除标本的组织学研究表明，肿瘤新生血管与多种人类肿瘤的预后及对治疗的反应相关。在9例成骨肉瘤或尤因肉瘤患者中，我们评估了磁共振血管造影（MRA）在体内非侵入性评估新生血管及监测化疗反应方面的应用。对7例骨肉瘤患者和2例尤因肉瘤患者在化疗前后进行了MRA检查（二维时间飞跃梯度回波序列，TR = 50毫秒，TE = 9.5毫秒，θ = 50度，采集时间13分钟）。评估MR血管造影以了解化疗引起的新生血管变化。MRA显示了供血血管和新生血管。6例患者对化疗有反应（组织学肿瘤坏死≥90%）。MRA显示所有有反应者的新生血管明显减少。3例患者对化疗无反应（组织学肿瘤坏死<90%）。MRA显示无反应者的新生血管持续存在或增加。MRA为在体内非侵入性研究肿瘤新生血管提供了独特的机会，并有助于评估成骨肉瘤或尤因肉瘤患者对化疗的反应。这些一般原则可能适用于其他人类肿瘤。
