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切尔诺贝利事故后人类小卫星突变率

Human minisatellite mutation rate after the Chernobyl accident.

作者信息

Dubrova Y E, Nesterov V N, Krouchinsky N G, Ostapenko V A, Neumann R, Neil D L, Jeffreys A J

机构信息

N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.

出版信息

Nature. 1996 Apr 25;380(6576):683-6. doi: 10.1038/380683a0.

Abstract

Germline mutation at human minisatellite loci has been studied among children born in heavily polluted areas of the Mogilev district of Belarus after the Chernobyl accident and in a control population. The frequency of mutation was found to be twice as high in the exposed families as in the control group. Mutation rate in the Mogilev families was correlated with the level of caesium-137 surface contamination, consistent with radiation induction of germline mutation.

摘要

在切尔诺贝利事故后,对白俄罗斯莫吉廖夫地区重污染区域出生的儿童以及对照组人群的人类小卫星位点的种系突变进行了研究。结果发现,暴露家庭中的突变频率是对照组的两倍。莫吉廖夫家庭的突变率与铯-137表面污染水平相关,这与种系突变的辐射诱导作用一致。

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