Morrow M J
Department of Neurology, UCLA School of Medicine, Sylmar, CA 91342, USA.
Neurology. 1996 Feb;46(2):514-21. doi: 10.1212/wnl.46.2.514.
I recorded smooth pursuit and saccadic eye movements in six patients with unilateral cerebral infarction. By comparing responses within the hemiranges of eye position to the right and left of the orbital midline and in rightward and leftward directions, I quantified craniotopic and directional ocular motor deficits. Two patients had ipsiversive gaze deviation and severe craniotopic defects in which they could not generate smooth pursuit or saccadic eye movement into the contralateral orbital hemirange. Three patients without gaze deviation generated worse smooth pursuit in the contralateral hemirange than in the ipsilateral hemirange, but each had symmetric saccades according to eye position. All patients with craniotopic pursuit defects also had directional smooth tracking asymmetries in which eye velocities were lower for targets moving ipsilaterally than for targets moving contralaterally. Craniotopic and directional defects were associated with damage in the frontal eye field region. Orbital position is taken into account by cerebral circuits that govern smooth pursuit and saccades.
我记录了6名单侧脑梗死患者的平稳跟踪和扫视眼动。通过比较眼位在眼眶中线左右半侧范围内以及向右和向左方向的反应，我量化了颅位性和方向性眼球运动缺陷。两名患者有同侧凝视偏斜和严重的颅位缺陷，他们无法产生向对侧眼眶半侧范围的平稳跟踪或扫视眼动。三名没有凝视偏斜的患者在对侧半侧范围内产生的平稳跟踪比同侧半侧范围内更差，但根据眼位，他们的扫视运动均对称。所有有颅位跟踪缺陷的患者也都有方向性平稳跟踪不对称，即向同侧移动的目标的眼速低于向对侧移动的目标。颅位性和方向性缺陷与额叶眼区的损伤有关。控制平稳跟踪和扫视的脑回路会考虑眼眶位置。
