Ikeshima H, Imai S, Shimoda K, Hata J, Takano T
Department of Microbiology, Keio University School of Medicine, Tokyo, Japan.
Neurosci Lett. 1995 Nov 17;200(2):117-20. doi: 10.1016/0304-3940(95)12092-i.
MEF2D, a member of myocyte-specific enhancer binding factor 2 (MEF2) gene family, was shown by Northern blot hybridization to be strongly expressed in the head portion of mouse embryos at later stages of ontogenesis, in the cerebellum and the cerebrum of adult mice, in cultured cell lines of neuronal origin, and in skeletal and cardiac muscles. During ontogenesis, MEF2D transcripts were detected by in situ hybridization in the olfactory bulb, entorhinal cortex, pyriform cortex, and hippocampus, in Purkinje and granule cells, and in large neurons in both the ventral and dorsal horns of spinal cord. Adult mice continued to express MEF2D in these limited areas of the central nervous system. Thus, MEF2D seems to be involved in either the differentiation process or the function of these neurons.
MEF2D是肌细胞特异性增强子结合因子2（MEF2）基因家族的成员之一，通过Northern印迹杂交显示，在个体发育后期的小鼠胚胎头部、成年小鼠的小脑和大脑、神经源性培养细胞系以及骨骼肌和心肌中均有强烈表达。在个体发育过程中，通过原位杂交在嗅球、内嗅皮质、梨状皮质和海马体、浦肯野细胞和颗粒细胞以及脊髓腹角和背角的大神经元中检测到MEF2D转录本。成年小鼠在中枢神经系统的这些有限区域中继续表达MEF2D。因此，MEF2D似乎参与了这些神经元的分化过程或功能。
