Schmitz D, Gloveli T, Heinemann U
Department of Neurophysiology, Humboldt University Berlin, Germany.
Neurosci Lett. 1995 Nov 17;200(2):141-3. doi: 10.1016/0304-3940(95)12087-k.
Losigamone is an anticonvulsant both in vivo and in vitro. We here studied possible mechanisms for such effects with conventional intracellular recordings from pyramidal cells of area CA1 and entorhinal cortex in combined hippocampal-entorhinal cortex slices. Losigamone reversibly reduced the number of action potentials elicited by 1 s long depolarising current injections. In addition, the drug moderately reduced EPSP amplitudes while monosynaptic fast and slow IPSPs were unaffected.
洛西加莫酮在体内和体外均具有抗惊厥作用。我们在此利用海马-内嗅皮层联合切片中CA1区和内嗅皮层锥体细胞的传统细胞内记录方法，研究了其产生这种作用的可能机制。洛西加莫酮可使1秒长的去极化电流注射所诱发的动作电位数量可逆性减少。此外，该药物适度降低了兴奋性突触后电位（EPSP）的幅度，而单突触快速和慢速抑制性突触后电位（IPSP）则未受影响。
