石棉暴露的尸检评估：对135例病例的回顾性研究，对消化肺组织中的含铁小体进行定量分析。

Autopsy evaluation of asbestos exposure: retrospective study of 135 cases with quantitation of ferruginous bodies in digested lung tissue.

作者信息

King J A, Wong S W

机构信息

Department of Pathology, University of South Alabama, Mobile, USA.

出版信息

South Med J. 1996 Apr;89(4):380-5.

PMID:8614876

Abstract

In recent years, there has been increased interest in documenting asbestos exposure. The pathologic sine qua non of asbestos exposure has been the presence of "asbestos bodies" in lung parenchyma. In this retrospective study of 135 autopsies done to determine asbestos exposure, ferruginous bodies in digested lung tissue were quantitated by a simplified sodium hypochlorite procedure on fresh or fixed tissue. Of the 131 digested specimens, 26 (20%) showed no ferruginous bodies, 34 (26%) had <5 ferruginous bodies per slide, 7 (5%) had 5 to 10 ferruginous bodies per slide, and 64 (49%) had >10 ferruginous bodies per slide. Ferruginous bodies were identified in hematoxylin-eosin stained sections of lung tissue in only 41 cases (30%). The digestion method described is a simple, reliable, and inexpensive method to assess ferruginous bodies.

摘要

近年来，记录石棉暴露情况的关注度有所提高。石棉暴露的病理关键在于肺实质中存在“石棉小体”。在这项对135例用于确定石棉暴露情况的尸检进行的回顾性研究中，通过一种简化的次氯酸钠程序对新鲜或固定组织中的消化肺组织中的含铁小体进行定量。在131个消化标本中，26个（20%）未显示含铁小体，34个（26%）每张玻片含铁小体少于5个，7个（5%）每张玻片含铁小体为5至10个，64个（49%）每张玻片含铁小体多于10个。仅在41例（30%）肺组织苏木精-伊红染色切片中发现了含铁小体。所描述的消化方法是一种评估含铁小体的简单、可靠且廉价的方法。