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粒细胞输注的临床结果(作者译)

[Clinical results with granulocyte transfusion (author's transl)].

作者信息

Mende S, Suchy B, Fülle H H, Pribilla W

出版信息

Med Klin. 1979 May 4;74(18):687-90.

PMID:86150
Abstract

16 adult patients with granulocytopenia and septicemia resistant to antibiotics received 42 granulocyte transfusions. The granulocytes were obtained from healthy donors with a blood cell separator by continuous flow centrifugation. Adding hydroxyethyl-starch an average of 1.8 X 10(10) leukocytes with 69% granulocytes were harvested in 3.5 hours. A small leukocyte increment after the transfusion was seen in half of the recipients. No correlation could be found between fever lysis and survival of the infection, which occurred in half of the cases too. A granulocyte transfusion is indicated in patients, who have granulocytopenia, sepsis and no evidence of bone marrow recovery.

摘要

16例对抗生素耐药的粒细胞减少症和败血症成年患者接受了42次粒细胞输注。粒细胞通过血细胞分离机从健康供体中经连续流动离心获取。平均加入羟乙基淀粉后,在3.5小时内收获了1.8×10¹⁰个白细胞,其中粒细胞占69%。半数接受者在输血后白细胞有少量增加。发热消退与感染存活之间未发现相关性,半数病例也出现了感染。对于有粒细胞减少症、败血症且无骨髓恢复迹象的患者,应进行粒细胞输注。

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