Heyer G, Ulmer F J, Schmitz J, Handwerker H O
Department of Dermatology, University of Erlangen/Nürnberg, Germany.
Acta Derm Venereol. 1995 Sep;75(5):348-52. doi: 10.2340/0001555575348352.
Alloknesis ("itchy skin") after histamine iontophoresis was studied together with itch sensations and skin reactions in 19 atopic eczema patients and 20 controls at the forearm and at the scapular area. Compared to controls, atopic eczema patients showed significantly reduced alloknesis or total lack of it in the area around a skin site to which histamine had been iontophoretically applied, although histamine elicited itching in most patients. As previously demonstrated, patients with atopic eczema also developed significantly smaller flares. However, covariance analysis revealed that the smaller alloknesis areas in atopic patients were not statistically related to the smaller flares. Our results suggest that in atopic eczema a diminished responsiveness of primary afferent nerves to histamine is not compensated by a higher central nervous sensitivity reflected in more vivid alloknesis responses to histamine. Therefore, we conclude that histamine is probably not the key factor of the spontaneous itch experienced by patients with atopic eczema.
我们对19名特应性皮炎患者和20名对照者的前臂及肩胛区域进行了研究，观察组胺离子导入后的异痒症（“皮肤瘙痒”）以及瘙痒感觉和皮肤反应。与对照组相比，特应性皮炎患者在组胺离子导入部位周围区域的异痒症显著减轻或完全没有，尽管组胺在大多数患者中引发了瘙痒。如先前所示，特应性皮炎患者出现的风团也明显较小。然而，协方差分析显示，特应性皮炎患者较小的异痒症区域与较小的风团在统计学上并无关联。我们的结果表明，在特应性皮炎中，初级传入神经对组胺的反应性降低，并不会因中枢神经系统更高的敏感性（表现为对组胺更强烈的异痒症反应）而得到补偿。因此，我们得出结论，组胺可能不是特应性皮炎患者自发瘙痒的关键因素。
