Bottomley W W, Jutley J, Wood E J, Goodfield M D
Department of Dermatology, Leeds General Infirmary, UK.
Acta Derm Venereol. 1995 Sep;75(5):364-6. doi: 10.2340/000155557575364366.
We examined the responsiveness of cultured dermal fibroblasts from biopsies of 6 patients with active morphoea and a similar number of matched controls to the cell proliferation inhibition activity of calcipotriol. Cultured fibroblasts from controls showed no significant response to calcipotriol (at concentrations of 1 x 10(-8) to 1 x 10(-4) M). However, calcipotriol did inhibit the proliferation response of morphoea fibroblasts at all concentrations when compared with controls. There was 4- to 20-fold inhibition in 2 of the morphoea patients when compared with control samples. Four other morphoea samples showed inhibition but to a lesser extent compared with controls.
我们检测了6例活动性硬斑病患者活检组织中培养的真皮成纤维细胞以及数量相近的匹配对照对卡泊三醇细胞增殖抑制活性的反应性。对照的培养成纤维细胞对卡泊三醇（浓度为1×10⁻⁸至1×10⁻⁴M）无明显反应。然而，与对照相比，卡泊三醇在所有浓度下均能抑制硬斑病成纤维细胞的增殖反应。与对照样本相比，2例硬斑病患者的细胞增殖受到4至20倍的抑制。其他4例硬斑病样本也表现出抑制作用，但程度低于对照。
