Dale P S, Giuliano A E
John Wayne Cancer Institute at Saint John's Hospital and Health Center, Santa Monica, Calif. USA.
Arch Surg. 1996 Apr;131(4):430-3. doi: 10.1001/archsurg.1996.01430160088019.
To determine if women with subareolar breast carcinoma can be successfully treated by breast-conserving therapy consisting of segmental mastectomy that preserves the nipple-areolar complex, axillary lymph node dissection, and postoperative irradiation.
Prospective study.
Tertiary care cancer center.
Twenty-five patients; median age, 56 years; median tumor diameter, 1.4 cm; and median follow-up, 48 months.
Breast-conserving therapy for subareolar primary breast carcinoma.
Two patients had positive surgical margins of resection, and another patient underwent simple mastectomy after developing a local recurrence. Nipple-areolar distortion was the most common cosmetic deformity after breast-conserving therapy, but overall cosmesis was good. At the most recent follow-up, all patients were free of disease.
Patients who have small subareolar primary breast carcinomas without evidence of nipple involvement are candidates for breast-conserving therapy with nipple-areolar preservation.
确定乳晕下乳腺癌女性患者能否通过保留乳头乳晕复合体的节段性乳房切除术、腋窝淋巴结清扫术及术后放疗组成的保乳治疗获得成功治疗。
前瞻性研究。
三级癌症护理中心。
25例患者；中位年龄56岁；肿瘤中位直径1.4厘米；中位随访时间48个月。
对乳晕下原发性乳腺癌进行保乳治疗。
2例患者手术切缘阳性，另1例患者出现局部复发后接受了单纯乳房切除术。保乳治疗后最常见的美容畸形是乳头乳晕变形，但总体美容效果良好。在最近一次随访时，所有患者均无疾病。
乳晕下原发性小乳腺癌且无乳头受累证据的患者是保留乳头乳晕的保乳治疗的候选者。
