Okada K, Suzuki N, Sugihara H, Minami S, Wakabayashi I
Department of Medicine, Nippon Medical School, Tokyo, Japan.
Brain Res. 1995 Nov 13;699(1):33-41. doi: 10.1016/0006-8993(95)00849-l.
In rats with anterolateral deafferentation of the medial basal hypothalamus, the growth hormone (GH) level in the blood showed irregular and small fluctuations instead of the usual high bursts and low trough level, and the baseline GH level was higher than that in sham-operated rats. Continuous infusion of a glucose solution to operated rats increased the baseline level, GH pulse and pulse amplitude. I.v. bolus injection of the glucose solution resulted in a significant but transient increase in GH level. Insulin-induced hypoglycemia decreased the blood GH level in operated rats more effectively than in sham-operated ones and that was prevented by simultaneous infusion of glucose. Since SS influence on GH secretion had been largely eliminated in rats with anterolateral deafferentation of the medial basal hypothalamus, it is highly unlikely that the effects of hyperglycemia or hypoglycemia on GH secretion were the consequence of altered SS secretion.
在接受下丘脑内侧基底部前外侧去传入神经支配的大鼠中，血液中的生长激素（GH）水平呈现不规则且微小的波动，而非通常的高峰和低谷水平，并且基线GH水平高于假手术大鼠。向手术大鼠持续输注葡萄糖溶液可提高基线水平、GH脉冲及脉冲幅度。静脉推注葡萄糖溶液会使GH水平显著但短暂升高。胰岛素诱导的低血糖在手术大鼠中比在假手术大鼠中更有效地降低了血液GH水平，而同时输注葡萄糖可预防这种情况。由于在接受下丘脑内侧基底部前外侧去传入神经支配的大鼠中，SS对GH分泌的影响已基本消除，因此高血糖或低血糖对GH分泌的影响极不可能是SS分泌改变的结果。
